In the New Jersey city of Newark, during the summer of 1944, a terrifying epidemic is raging, threatening children with maiming, paralysis, life-long disability, even death. At the centre of Nemesis is a vigorous, dutiful, twenty-three-year old playground director, Bucky Cantor, a javelin thrower and a weightlifter, who is devoted to his charges and whose weak eyes have excluded him from serving in the war. Focusing on Cantor's dilemmas as polio begins to ravage his playground Roth leads us through every inch of emotion such a pestilence can breed: the fear, the panic, the anger, the bewilderment, the suffering, and the pain.